Cisplatin macrophage

WebIn IL-4-activated macrophages (M2 macrophages), the Krebs cycle and oxidative phosphorylation are intact and fatty acid oxidation (FAO) is also utilized. These metabolic alterations in response to the nature of the stimulus are proving to be determinants of the effector functions of M1 and M2 macrophages. WebFor the first time, in vitro studies on cisplatin exposure addressed human monocytes and monocyte-derived macrophages (undifferentiated THP-1 monocytic cells, differentiated …

Selective depletion of a CD64-expressing phagocyte subset ... - PNAS

WebDec 2, 2024 · The use of resveratrol with cisplatin inhibited suppressed tumor growth when compared with cisplatin alone. Conclusion This study revealed that resveratrol inhibited breast cancer cell proliferation by promoting M1/M2 macrophage polarization ratio and suppressing IL-6/pSTAT3 pathway. Introduction WebBackground: Phosphoribosyl pyrophosphate synthetases 2 ( PRPS2) is reported as an oncogene in various cancers. However, the role of PRPS2 in cisplatin (DDP) resistance of non-small cell lung cancer (NSCLC) remains unclear. The present study aimed to explore the effect of PRPS2 in DDP resistance of NSCLC. images of reflection quotes https://qandatraders.com

M2 macrophage polarization modulates epithelial-mesenchymal transition ...

WebAug 24, 2024 · 1. Introduction. Cisplatin (CDDP), a platinum-based anticancer agent, is one of the most commonly used chemotherapy drugs in the treatment of patients with various types of cancer, such as bladder, ovarian, head and neck, lung, testicular, cervical, esophageal, and breast cancer [].CDDP and its analogs, carboplatin and oxaliplatin, … WebJan 24, 2024 · The results suggested that SQFZ could inhibit MDA-MB-231/DDP cell growth related to M2 macrophages. When cisplatin was used in combination with SQFZ 40 … WebJan 24, 2024 · When cisplatin was used in combination with SQFZ 40 μl/mL, the survival in the cisplatin 60 μM and 120 μM groups reduced by 50.8% and 72.5%, respectively, in the co-cultured MDA-MB-231/DDP cells and M2 macrophages . These results suggested that SQFZ improved the sensitivity of cisplatin through M2 macrophages. images of refinished furniture

New Insights into Mechanisms of Cisplatin Resistance: From …

Category:Cisplatin does not affect the phenotype of CAMs, or the

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Cisplatin macrophage

Original research: CircITGB6 promotes ovarian cancer cisplatin ...

WebCisplatin decreases mitochondrial function in sensory axons, and HDAC6 inhibition can promote axonal transport of healthy mitochondria. Indeed, the HDAC6 inhibitor normalized cisplatin-induced tibial nerve mitochondrial deficits. However, this was independent of macrophages and IL-10 signaling. WebJan 31, 2024 · Here, we investigated the effects and mechanisms of cisplatin (DDP) on intracellular Mycobacterium smegmatis to tap the therapeutic potential of DDP in …

Cisplatin macrophage

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WebOct 3, 2024 · Blocking Macrophage Migration Inhibitory Factor Protects Against Cisplatin-Induced Acute Kidney Injury in Mice. Macrophage migration inhibitory factor (MIF) is … WebNational Center for Biotechnology Information

WebJul 1, 2013 · Cisplatin is widely used to treat cancer, and one of its limiting side effects is acute kidney injury characterized by acute tubular necrosis … WebJun 6, 2024 · Herein, a potent strategy to construct a macrophage-mediated drug delivery platform loaded with a nanosphere (CpG-ASO-Pt) (CAP) composed of functional nucleic …

WebMar 8, 2024 · Our data indicated that cell damage induced by cisplatin activated TIM3 on CD8+ T cells, leading to increased IL-13 production, which in turn induced macrophage IL-10 production and resolution of CIPN. Development of exogenous activators of the IL-13/IL-10 pain resolution pathway may provide a way to treat the underlying cause of chronic pain. WebJun 11, 2024 · VNS treatment significantly suppressed cisplatin-induced kidney injury. This effect was abolished by splenectomy, while adoptive transfer of GTS-21-treated …

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WebCisplatin does not affect the phenotype of CAMs, or the anti-tumor and chemo-sensitivity effects of CAMs on ovarian cancer cells. (A) mRNA expression of macrophage polarization markers as... images of refinished dressersWebApr 1, 2016 · Cisplatin is currently one of the most effective chemotherapeutic drugs used for treating ovarian cancer; however, resistance to cisplatin is common. In this study, we explored an experimental strategy for overcoming cisplatin resistance of human ovarian cancer from the new perspective of cancer cell metabolism. list of best mutual funds for sipWebMacrophage Stimulating Protein May Promote Tubular Regeneration after Acute Injury . × Close Log In. Log in with Facebook Log in with Google. or. Email. Password. Remember me on this computer. or reset password. Enter the email address you signed up with and we'll email you a reset link. ... list of best multivitaminsWebApr 11, 2024 · Sorafenib induces macrophage pyroptosis, ... The chemotherapy drug cisplatin (DDP) combined with low-dose BI2536, a polo-like Kinase 1(PLK1) inhibitor, can increase chemosensitivity by inducing ... images of reflectingWebApr 13, 2024 · Background. Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the … list of best mystery authorsWebNov 30, 2024 · For the first time, in vitro studies on cisplatin exposure addressed human monocytes and monocyte-derived macrophages (undifferentiated THP-1 monocytic … images of refugees grocery shoppingWebSep 13, 2024 · Our findings in cisplatin-induced injury underscore the value of dissecting the functions of individual MP subsets in kidney disease, which may enable therapeutic targeting of specific immune components in the absence of general immunosuppression. Sign up for PNAS alerts. Get alerts for new articles, or get an alert when an article is cited. images of refinished kitchen cabinets