Gata4 hypertrophy

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August undefined, 2024

WebMar 15, 2016 · To examine whether deletion of Gata4 in cardiomyocytes results in cardiomyocyte hypertrophy of the adult hearts after injury, we co-stained with the lectin-specific marker wheat germ agglutinin (WGA) and … WebApr 19, 2024 · Gesine M. Dittrich,#1,2,8Natali Froese,1Xue Wang,#1,3Hannah Kroeger,1Honghui Wang,1Malgorzata Szaroszyk,1Mona Malek-Mohammadi,2,8Julio Cordero,4Merve Keles,2Mortimer Korf-Klingebiel,1Kai C. Wollert,1Robert Geffers,5Manuel Mayr,6Simon J. Conway,7Gergana Dobreva,4,8Johann Bauersachs,1and Joerg …

UniProt

WebGATA4 has been related to cardiac myocyte hypertrophy (Kobayashi et al., 2007; Liang et al., 2001; Oka et al., 2006). Recently, the GATA4 gene was reported to be required for the direct reprogramming of cardiac myocytes from cardiac fibroblasts ( Ieda et al. , 2010 ). WebMar 28, 2024 · Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 1998 Apr 17;93(2):215-28. doi: 10.1016/s0092-8674(00)81573-1. fux ipari szolgáltató és kereskedelmi zrt

Anti-GATA4抗体 - 上海康朗生物科技有限公司

WebJun 28, 2024 · Unlike from our previous findings, here, NEU1 plays a non-canonical role as a co-activator to interact with transcriptional factors GATA4, promoting cardiac hypertrophy and remodelling. This study combined with our previous work showed that NEU1 is a key driver of cardiovascular disease, and is therefore a potential therapeutic target. WebHasegawa et al. (1997) concluded that interaction between GATA4 and the GATA element plays a role in the transcriptional activation of MYH7 during pressure overload cardiac hypertrophy. Similar evidence implicating GATA4 as a mediator of cardiac hypertrophy was presented by Herzig et al. (1997). WebDec 31, 2013 · These results indicate that GATA-4 and GATA-6 play a dosage-dependent and redundant role in programming cardiac hypertrophy, but that each has a more complex role in maintaining cardiac homeostasis and resistance to heart failure following injury that cannot be compensated by the other. fux jelentése

The Transcription Factors GATA4 and GATA6 Regulate …

Webdf 肽给药以及运动降低了血清中的血压和心脏标志物水平。此外，它还抑制纤维化标志物 col1a1、ctgf、和 upa 和下调的心脏肥大相关标志物，如钙调神经磷酸酶、nfatc3、gata4、pgata4 和 bnp。运动协同增加 ifg1、pi3k 和 akt 细胞存活途径蛋白的表达，以及 df 给药。 WebFeb 14, 2024 · GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis. GRP78 increases GATA4 (GATA-binding protein 4) level, which may stimulate Anf (atrial natriuretic factor) expression and promote cardiac hypertrophic growth. atex laitteetWebApr 4, 2024 · Mutational analysis of the GATA4 gene in Chinese men with nonobstructive azoospermia. TFEB insufficiency promotes cardiac hypertrophy by blocking autophagic degradation of GATA4. GATA4 blocks squamous epithelial cell gene expression in human esophageal squamous cells. atex kf94 hello kitty

"WebFeb 26, 2024 · the acetylation of GATA4 as one of critical nuclear events in myocardial cell hypertrophy. Increased GATA4 protein degradation may be an important mechanism that contributes to hyperglycemic cardiotoxicity. GATA-4 is a novel downstream effector of … " - Gata4 hypertrophy

Gata4 hypertrophy

Entry - *600576 - GATA-BINDING PROTEIN 4; GATA4 - OMIM

WebAug 1, 2024 · GATA binding protein 4 (GATA4) was identified as the key target regulated by YXS. The results of mass spectrometry image analysis indicated that the expressions of histone deacetylase 1 (HDAC1) and retinoblastoma (RB) could also be regulated by YXS. WebOct 19, 2024 · It has been demonstrated that activation of NF-κB signaling contributes to the development of cardiac hypertrophy. 16 Immunoblotting of left ventricle tissue isolates from WT TAC-operated mice showed increased phosphorylation of NF-κB pathway factors IKKα/β, IκBα, and p65 at 2 and 8 weeks postinjury.

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WebA zinc finger protein, GATA4, is one of the hypertrophy-responsive transcription factors, forms a functional protein complex with an intrinsic histone acetyltransferase, p300, and regulates pathological cardiac hypertrophy. Disruption … WebMay 1, 2015 · GATA4, a member of the GATA family of zinc finger transcription factors, is crucial for normal cardiac development, 14 and in the adult heart GATA4 is centrally involved in regulating cardiac hypertrophy. 15 GATA4 has been shown to be phosphorylated by ERK leading to enhanced GATA4-DNA binding and activation of the …

WebAug 10, 2001 · GATA4 DNA Binding Activity Is Augmented by Hypertrophic Agonist Stimulation To investigate the role of GATA factors as hypertrophic regulators, we first examined whether expression of GATA4 or GATA6 was altered by hypertrophic stimuli. WebSep 24, 2014 · GATA4 occupancy studies of control versus pressure overloaded adult heart similarly showed that some fetal GATA4-bound regions were restored in cardiac hypertrophy, but most...

WebGATA4 has been related to cardiac myocyte hypertrophy (Kobayashi et al., 2007; Liang et al., 2001; Oka et al., 2006 ). Recently, the GATA4 gene was reported to be required for the direct reprogramming of cardiac myocytes from cardiac fibroblasts ( Ieda et al., 2010). WebGata4. Status. UniProtKB reviewed (Swiss-Prot) Organism. Rattus norvegicus (Rat) Amino acids. 440. Protein existence. Evidence at protein level. Annotation score. 5/5. ... CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with NR5A1, ZFPM2 and TBX5. Interacts with ZNF260. Interacts with TBX18 …

WebAug 5, 2024 · The lysosomal inhibitor bafilomycin A1 increases the levels of GATA4 at the basal state (Fig 5C and 5D), suggesting that GATA4 is constitutively degraded by autophagy. It remains to be determined why this is the case. GATA4 is an evolutionarily conserved transcription factor that is crucial for development of the heart, liver, and …

WebAug 15, 2004 · While a large number of signal transduction cascades have been identified as critical regulators of cardiac hypertrophy, here the scientific evidence implicating the protein phosphatase calcineurin (PP2B) and the mitogen-activated protein kinases … fuxholzenWebIt is also interesting to note that cardiac-specific deletion of Gata4 only reduced the cardiac hypertrophic response by approximately 40% to 50%, suggesting either that other regulators are sufficient to mediate some … fuxi azerWebMar 15, 2024 · Acetylation of H3K9 and H3K27 has also been suggested to be involved in the expression of GATA4, as GATA4 is involved in the development of HF and the fetal gene is reactivated during HF, suggesting that the acetylation of H3K4 may be involved in cardiac hypertrophy and HF (25, 26). atex logistykaWebIn addition, it downregulated the levels of ANP, β-MHC, CaSR, CaN, NFAT3, phosphorylated GATA4 (p-GATA4), PKC-β, Raf-1, and p-ERK 1/2; and upregulated the levels of p-NFAT3 and MKP-1. These results suggest that the effects of SF on cardiac hypertrophy are related to regulation of the CaSR-mediated signaling pathway. atex luokitteluWebThe inhibition of p300-dependent acetylation of GATA4 suppresses the transcription of cardiac hypertrophic response genes, cardiomyocyte hypertrophy, and the development of heart failure, suggesting that regulation of the transcriptional activity of GATA4 could serve as a novel therapeutic strategy for heart failure [11, 12]. atex luokitusWebTranscriptional synergy based on protein-protein interaction involving GATA4 and these transcriptional factors may be implicated in the … fuxia virágWeb上海康朗生物科技有限公司主要致力于“Anti-GATA4抗体”的生产销售。多年的“Anti-GATA4抗体”生产与销售的经验，与各行业新老用户建立了稳定的合作关系，我公司经营的产品名称深受广大用户信赖。欢迎来电咨询或前来选购。联系电话：021-61998208。 fuxolás